Front-line Research of Idiosyncratic Drug Toxicity
نویسندگان
چکیده
منابع مشابه
Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure–Toxicity Relationships
Adverse drug reactions (ADRs) continue to be a significant contributor to overall attrition statistics in the pharmaceutical industry. ADRs pose a significant health problem since they contribute to patient morbidity and mortality and represent one of the most common causes for pharmaceutical product recalls and black-box warning labels. Of a total of 548 drugs approved in the period from 1975 ...
متن کاملCovalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.
Bioactivation of a drug to a reactive metabolite and its covalent binding to cellular macromolecules is believed to be involved in clinical adverse events, including idiosyncratic drug toxicities (IDTs). For the interpretation of the covalent binding data in terms of risk assessment, the in vitro and in vivo covalent binding data of a variety of drugs associated with IDTs or not were determined...
متن کاملComputational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity
Idiosyncratic drug toxicity (IDT), considered as a toxic host-dependent event, with an apparent lack of dose response relationship, is usually not predictable from early phases of clinical trials, representing a particularly confounding complication in drug development. Albeit a rare event (usually <1/5000), IDT is often life threatening and is one of the major reasons new drugs never reach the...
متن کاملMisbehaviors of front-line research personnel and the integrity of community-based research.
There has been little empirical research into misconduct and misbehavior among community research workers who recruit and collect data in vulnerable and marginalized health populations and are also members of those same communities. We conducted qualitative interviews with community research workers and traditional research assistants to understand the context and consequences of misbehaviors t...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2015
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.14-00249-f